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- W2360000741 abstract "Objective To explore the mechanism of nerve growth factor (NGF) treating Alzheimer’s disease (AD). Methods Rat models of AD were established with β amyloid protein (Aβ), and NGF was injected by intracerebroventricular. The behavior change of rats was observed and ChAT activity was measured with liquid scintillation counter. Results The learning impairment and the memory deficits of rats was observed, and ChAT activity decreased after injection of Aβ. The learning ability and memory were improved and ChAT activity was increased after infusion of NGF.Conclusions These results suggested that the one of mechanisms of therapy of NGF for AD is increasing ChAT activity to resume the function of cholinergic nerve." @default.
- W2360000741 created "2016-06-24" @default.
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- W2360000741 date "2004-01-01" @default.
- W2360000741 modified "2023-09-27" @default.
- W2360000741 title "The establishment of animal model of Alzheimer's disease and the effect of NGF on ChAT" @default.
- W2360000741 hasPublicationYear "2004" @default.
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