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- W2360001475 abstract "Objective To investigate the effects of Shuanghu qinggan granule on gene expression in liver injury induced by carbon tetrachloride in rats.Methods Sixty Sprague-Dawley rats were divided into 6 groups,namely normal control group(A),model group(B),Shuanghu qinggan granule low(C1),medium(C2),high(C3) dose group and silymarin positive contrast group(D).The rats of group B,C1,C2,C3 and D were subcutaneously injected by carbon tetrachloride (3 mL/kg body weight) twice a week for 8 weeks.The rats of group C1,C2,C3 were then administered with Shuanghu qinggan granule at the doses of 5 g/kg body weight(C3),2.5 mg/kg body weight(C2),1.2 g/kg body weight(C1) for 8 weeks.The rats of group D were then administered with silymarin at a dose of 50 mg/kg body weight.The changes of some gene expression were detected by gene chip techonology.Results After the intervention,the rats in group A had no significant changes in gene expression.Compared with group A,the reduced expression of the genes of rats of group B,C1,C2,C3,D were as follows after the intervention of carbon tetrachloride: CY-related genes,lipid metabolism related genes,protein glycosylation-related genes;the upregulated expression of the genes of rats of group B,C1,C2,C3,D were as follows: the cell cycle and apoptosis-related genes,fat transfer related genes,involved in cell adhesion and cell connections and the formation of collagen genes.Compared with group B,the following genes of rats of group C1,C2,C3,D were up-regulated after the intervention of Shuanghu qinggan granule: CY-related genes,protein glycosylation-related genes,lipid metabolism related genes.Before and after the intervention of Shuanghu qinggan granule,gene expressions of rats of group C1,C2,C3 up-regulated compared to pre-intervention when they were down-regulated,down-regulated compared to pre-intervention when they were up-regulated.Involved in cell adhesion and cell connection and the formation of collagen gene. The cell cycle and apoptosis-related genes appeared to interfere with the most of the changes in gene expression also increased.The changes of gene expression in rats caused by Shuanghu qinggan granule was different from those caused by silymarin(some down-regulated,some no change,some up-regulated).Conclusion Shuanghu qinggan granule could have the potential to relieve liver injury caused by carbon tetrachloride through genetic pathways with a remarkable dose-response correlation." @default.
- W2360001475 created "2016-06-24" @default.
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- W2360001475 date "2009-01-01" @default.
- W2360001475 modified "2023-09-23" @default.
- W2360001475 title "Effects of Shuanghu qinggan granule on gene expression in liver injury induced by carbon tetrachloride in rats" @default.
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