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- W2360007906 abstract "Objective To explore the relation between natural killer(NK) and both clue cell and dysbacteriosis for patients with bacterial vaginosis.Methods 21 patients as well as 16 health married women were enrolled in this study,whose peripheral blood was collected to test the ratio of NK.The serum level of IFN-γ and IL-5 were detected through ELISA to reflect the function of NK indirectly.Vaginal smear was made and the clue cells were counted.The mRNA of TLR4,an important factor could induce dysbacteriosis was detected by quantitative PCR.Results The ratio of NK in the BV patients was(10.60±4.22) %,significantly lower than(18.80±2.77) % in the healthy women(p=0.007).The cytokines of NK,IFN-γ and IL-5,were apparently lower in the BV patients when compared with the healthy ones(p=0.026,p=0.035).The ratio of clue cells in the BV patients was(17.62±4.45)%,obviously higher that in the healthy women(2.02±0.67)%(p=0.000),so was the TLR4mRNA [(2.69±1.68)×105 in the BV patients vs(6.77±2.86)×103 in the healthy ones copies/μl,p=0.008)].Pearson analysis showed that natural killer correlated with both clue cell and TLR4(standing for dysbacteriosis to some extent) negatively(p=0.006,p=0.010).Conclusion Our finding,low in quantity and weakness in function for NK,might result in both the persistent state of dysbacteriosis and the increase of clue cells,indicating a potential immunological mechanism for bacterial vaginosis." @default.
- W2360007906 created "2016-06-24" @default.
- W2360007906 creator A5083401989 @default.
- W2360007906 date "2011-01-01" @default.
- W2360007906 modified "2023-09-25" @default.
- W2360007906 title "NATURAL KILLER CORRELATED WITH BOTH CLUE CELL AND DYSBACTERIOSIS NEGATIVELY FOR PATIENTS WITH BACTERIAL VAGINOSIS" @default.
- W2360007906 hasPublicationYear "2011" @default.
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