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- W2360014262 abstract "Objective To investigate the protective effect of chitosan oligosaccharide(COS) on carbon tetrachloride(CCl4)-induced liver damage in male ICR mice and the possible mechanisms involved.Methods Liver damages of male ICR mice were produced by celiac injection with CCl4(20 mg·kg-1).Mice of experimental group were pretreated with COS(1.5 g·kg-1) once daily for 12 consecutive days.Twenty-four hours after the administration of CCl4,blood was collected and serum was separated for determination of the activities of alanine aminotransferase(ALT) and aspartate aminotransferase(AST).Then the animals were sacrificed by cervical decapitation,and their livers were dissected out.Total antioxidant capabilities(T-AOC),sulfhydryl content,metallothionein(MT) and malondialdehyde(MDA) quantification in liver homogenate were measured and qualitative analysis of liver DNA fragmentation was carried out.Results Serum ALT and AST activities and MDA formation in COS pretreated group were decreased to 62.2%,52.9% and 34.3%,respectively,compared to those in CCl4 group.T-AOC and NP-SH contents were improved to 26.1% and 16.3%.Pretreatment with COS could significantly increase MT expression to 2.15 fold of the control.However,COS showed no effect on increasing the content of T-SH.DNA isolated from the COS group and the CCl4 group both showed the fragmentation about 1 kb via agarose gel electrophoresis.Conclusions The results indicate that pretreatment with COS could efficiently improve the antioxidant activity and protect mice against CCl4 induced liver damage,but genotoxicity could not be mitigated." @default.
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- W2360014262 date "2008-01-01" @default.
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- W2360014262 title "Antioxidant and hepatoprotective activities of chitosan oligosaccharide" @default.
- W2360014262 hasPublicationYear "2008" @default.
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