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- W2360022290 abstract "Inflammatory bowel disease(IBD),including ulcerative colitis(UC) and Crohn's disease(CD),is characterized by periodic relapses and remissions.UC and CD are considered to be more frequent in western countries but relatively infrequent in China.However,recent reports have indicated an increase in both incidence and prevalence rates in China.The etiology of IBD remains unclear,but it is widely accepted that genetic,environmental and immunological factors are involved.Not only for detecting potential therapeutic agents,but also for investigating the mechanisms of pathogenesis have been developed and proved in animal models of experimental colitis.In this review,we mainly focus on four main categories based on the methods of induction: chemical,genetically-engineered,adoptive transfer and spontaneous(each with subcategories,mechanisms,establishing methods,features and the application).Complementary to this,the characteristic features of ideal animal models are summed up.Finally,we discuss the possible etiology demonstrated by these models as well as the relationship between IBD animal models and human IBD." @default.
- W2360022290 created "2016-06-24" @default.
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- W2360022290 date "2011-01-01" @default.
- W2360022290 modified "2023-09-26" @default.
- W2360022290 title "Recent advances in experimental animal models of inflammatory bowel disease" @default.
- W2360022290 hasPublicationYear "2011" @default.
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