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- W2360036517 abstract "Objective: To investigate the changeable patterns of microsatellite instability(MSI)in intestinal metaplasia(IM)and gastric cancer(GC)and the role of MSI in gastric carcinogenesis. Methods: Silver staining single strand conformation polymorphism-polymeriase chain reaction(PCR-SSCP)was used to screen MSI markers at 5 loci in formalin-fixed,paraffin-embedded tissues of GC(n=30),IM(n=40)and corresponding normal gastric tissues. Results: The abnormal shifting of the single-strand DNA was identified in 7(23.3%)out of GC and in 8(20%)out of IM samples.Three(10%)tumors and one(2.5%)IM displayed high-frequency MSI(two or more loci altered).Low-frequency MSI(one loci altered)was detected in 4(13.3%)of the tumors and in 7(17.5%)IM samples.GC with MSI was associated with distal location of the tumors but age,sex,differentiation,lymph nodes metastasis and TNM stage(P=0.044).MSI was more likely detected in moderate-grade IM than in mild-grade IM tissues(34.8% versus 0; P=0.013); and MSI had a tendency to be easily detected in female with IM. Conclusion: The progressive accumulation of MSI in areas of IM may contribute to GC development,representing an important molecular event in the multistep gastric carcinogenesis." @default.
- W2360036517 created "2016-06-24" @default.
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- W2360036517 date "2004-01-01" @default.
- W2360036517 modified "2023-09-24" @default.
- W2360036517 title "Microsatellite Instability in Intestinal Metaplasia and Gastric Cancer" @default.
- W2360036517 hasPublicationYear "2004" @default.
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