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- W2360041667 abstract "Objective To investigate the immunologic mechanism of low dose mifepristone as an anti-implantation contraceptive drug.Methods Endometrial biopsies were obtained from fourteen normally cycling women during the receptive phase.Each endometrial tissue,divided into three equal parts,was assigned to three groups:control group,65 nmoL/L mifepristone group(group A)and 200 nmol/L mifepristone group(group B).Endometrial explants were cultured in vitro.The numbers of natural killer cells and the percentages of CD_3~-CD_(56)~+ CD_(16)~+ subset and CD_3-CD_(56)~+ CD_(16)~+ subset were analysed by immunohistochemistry and flow cytometry.Results(1)The mean number of CD_(56)~+NK cells in group A (148±11)and group B(150±12)were significantly higher when compared to the control group(121±7, P0.05).There was no significant difference between the two mifepristone-treated groups(P0.05).(2) The percentage of CD_3~-CD_(56)~+ NK cells in group A(44±5)% and in group B(48±4)% were significantly higher when compared to the control group(35±3)%,(P0.05),there was no significantly difference between the two mifepristone-treated groups(P0.05);The percentage of CD_3~-CD_(56)~+ CD_(16)~+ subset in group A (42±5)% and in group B(45±5)% were significantly higher when compared to the control group(33± 3)%,(P0.05),there was no significantly difference between the two mifepristone-treated groups(P 0.05);the percentages of CD_3~-CD_(56)~+ CD_(16)~+ subset in three groups [(2.70±0.24)%,(3.26±0.37)% and (2.33±0.29)%] were not significantly different(P0.05).Conclusion Low dose mifepristones increase the number of CD_(56)~+ NK cells and the percentage of CD_3~-CD_(56)~+ CD_(16)~-NK subset,which might result in the disturbance of human endometrial immuno-mieroenviromnent during receptive phase and lead to imolantation failure." @default.
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- W2360041667 date "2007-12-01" @default.
- W2360041667 modified "2023-09-24" @default.
- W2360041667 title "Effects of low dose mifepristone on population and subsets of natural killer cells in human endometrium during receptive phase" @default.
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