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- W2360050233 abstract "To study the effects of hydroxycamptothecine(HCPT) combined with mitomycin on human leukemic K562 cells,and to explore the mechanism of that induced apoptosis.After the effect of MMC、HCPT and both combined for different concentration,trypan blue staining was performed to detect cell growth inhibition rate and calculated CI,flow cytometry(FCM) was used to detect the apoptosis rate of K562 cells,morphological changes of the apoptosis in K562 cells were observed through AO fluorescent staining under fluorescent microscope and transmission electron microscope.The results show,when the combination of the two drugs,CI is 0.78 for synergistic effect.MMC、HCPT and both combined all can induce apoptosis in K562 cells.The apoptosis rate for the combination of the two drugs was higher than that for alone.The combination of HCPT and MMC can induce apoptosis,and had synergistic inhibiton effects on the growth of human leukemic K562 cells." @default.
- W2360050233 created "2016-06-24" @default.
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- W2360050233 date "2012-01-01" @default.
- W2360050233 modified "2023-09-23" @default.
- W2360050233 title "The research on apoptosis in human leukemic K562 cells acted by HCPT and MMC" @default.
- W2360050233 hasPublicationYear "2012" @default.
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