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- W2360058378 abstract "Objective To design and prepare a tissue microarray of laryngeal and hypopharyngeal squamous cell carcinoma(LHSCC) and study CD44v6 expression in larynx and hypopharynx carcinoma by immunohistochemistry and analyze the relationship between CD44v6 expression and biological behavior of LHSCC using the tissue microarray.Methods One hundred and twenty five tissues of primary cancer,normal tissue,and metastatic carcinoma were obtained during operation.These tissues were fixed in formalin and were embedmented with paraffin.A tissue microarray was made by using these paraffin-embedded tissues.The expression of CD44v6 in laryngeal and hypopharyngeal squamous cell carcinoma was studied by immunohistochemistry in the tissue microarray,and the clinical significance of CD44v6 expression was analyzed.Results In primary cancer tissue,the expression rate of CD44v6 was significantly higher than that in normal tissue(P0.05);the rate in lymph node metastatic carcinoma was significantly higher than that in normal tissue(P0.001)and primary cancer tissue(P0.01);CD44v6 expression rate of the group with lymph node metastasis was significantly higher than that in group without lymph node metastasis(P0.01);the expression rate of the well-differentiated group was higher than that in moderately differentiated group(P0.05).Conclusion There is an overexpression of CD44v6 in larynx and hypopharynx carcinoma,the expression rate was concerned with degree of cell differentiation and metastasis of lymph node.CD44v6 overexpression may become a predict index of metastasis and prognosis of laryngeal and hypopharyngeal squamous cell carcinoma." @default.
- W2360058378 created "2016-06-24" @default.
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- W2360058378 date "2008-01-01" @default.
- W2360058378 modified "2023-09-27" @default.
- W2360058378 title "Expression and clinical significance of CD44v6 in tissues of laryngeal and hypopharyngeal squamous cell carcinoma" @default.
- W2360058378 hasPublicationYear "2008" @default.
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