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- W2360060861 abstract "Objective:To determine the effects of osthole on voltage-dependent calcium channel subtypes.Methods:tsA-201 cells were transfected with the calcium channel subtypes of Cav1.2,Cav1.3,Cav2.2e[37a],and Cav2.2e[37b].The calcium currents were recorded in tsA-201 cells using whole cell patch clamp technique.The effects of osthole on calcium currents were investigated.Results: Osthole could inhibit Cav1.2 and Cav1.3 currents in a concentration - dependent manner.The half-effective concentration of the inhibition was 162.1μmol·L~(-1),and 56.2μmol·L~(-1),respectively.In addition,Osthole reduced the Cav2.2e[37a],and Cav2.2e[37b] currents by 38%,and 61%,respectively,at the concentration of 300μmol·L~(-1).The inhibition was fast and reversible.Osthole decreased the current amplitudes at all tested potentials,but showed no significant influence on the activation kinetics of the above calcium channels subtypes.Conclusions:Osthole concentration - dependently inhibited calcium currents and displayed different affinity to the calcium channel subtypes." @default.
- W2360060861 created "2016-06-24" @default.
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- W2360060861 date "2011-01-01" @default.
- W2360060861 modified "2023-10-18" @default.
- W2360060861 title "Effect of Osthole on L-and N-type Calcium Channels" @default.
- W2360060861 hasPublicationYear "2011" @default.
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