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- W2360079361 abstract "A set of bioinformatics methods were used to screen novel human secretory proteins from many protein sequences obtained from the public protein database in this study.A novel secretory protein gene,CHID1 was obtained.It locates in human chromosome 11p15.5,spanning 1 182 bp and encoding 393 amino acid residues.Transfecting in COS-7 cell and subsequently western blot analyzing showed that CHID1 was not detected in cell culture media.Tissue RT-PCR experiment uncovered that CHID1 was(expressed) in lung,kidney,liver,heart and thymus,but highest in liver.Lovo-CHID1 stable cell lines were established and cell growth curve was described.It was discovered that the growth rate of Lovo-CHID1 stable cell lines was inhibited.And cell cycle analysis supported that G1 phase of stable cell lines was(arrested.) So CHID1 may be a potential tumor suppressor gene." @default.
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- W2360079361 date "2007-01-01" @default.
- W2360079361 modified "2023-09-25" @default.
- W2360079361 title "Molecular Cloning and Preliminary Functional Study of Human Novel Gene CHID1" @default.
- W2360079361 hasPublicationYear "2007" @default.
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