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- W2360090799 abstract "Objective To study the mechanism of solanine on apoptosis in HepG2 cell.Methods Morphology of apoptosis was observed by electron microscope;TUNEL Assay was adopted to observe the DNA cleavage of apoptotic cells,apoptosis rate was analyzed by flow cytomety.Indirect immunofluorescence assay was adopted to study the Bcl-2/Bax protein by Laser Confocal Scan Microscope.Relative caspase-3 activity was determined by colorimetric assay.Results Characteristic morphology of apoptosis,such as shrinkage,chromatin dense,nuclear condensation pool,the nuclear fragments,and apoptotic bodies,etc.was found.By TUNEL assay,DNA fragmentation was found in solanine groups,but none in control group.The early apoptosis rates induced by 0.4,2,and 10 mol/L solanine were 4.0%,8.5%,and 20.1%,respectively.And solanine increased caspase-3 activity of HepG2 cells and decreased the Bcl-2 protein expression,increased the Bax protein expression.Conclusion Solanine could induce the HepG2 cell apoptosis by decreasing the Bcl-2 protein expression,increasing the Bax protein expression to activate the caspase-3 activity." @default.
- W2360090799 created "2016-06-24" @default.
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- W2360090799 date "2009-01-01" @default.
- W2360090799 modified "2023-09-27" @default.
- W2360090799 title "Induction of solanine on HepG2 cell apoptosis by regulation of Bcl-2/Bax expression and caspase-3 activity" @default.
- W2360090799 hasPublicationYear "2009" @default.
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