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- W2360098703 abstract "Objective To explore the time-effect and dose-effect of fluoride on lipid peroxidation and cell apoptosis in rats.Methods Sixty male Sprague-Dawley rats were randomly divided into 3 sets.In every set,the rats were randomly divided into 4 groups,which were fed with water containing sodium fluoride at the dosage of 0,10,50 and 100 mg / L for 60,90,120 d,respectively.Malonaldehyde(MDA) content and cell apoptosis rate in liver was measured by TBA method and flow cytometry(FCM),respectively.Results Compared with control group at the same feeding time,MDA content of liver in moderate and high dose fluoride groups for 60,90 and 120 d all increased.The Pearson correlation coefficient between MDA and sodium fluoride dose were 0.98,0.99 and 0.98(P 0.01).In comparison with control group at the same fluoride doses,the Pearson correlation coefficient were 0.98,0.95 and 0.89(P 0.05).This result indicated that there was significant positive correlation between MDA content and fluoride doses(feeding time).In comparison with the control groups,at the same fluoride doses,the cell apoptosis in high dose fluoride groups for 60 d and all fluoride groups for 90 d increased obviously.The Pearson correlation coefficient between MDA and feed time were 0.97,0.81,and 0.94(P 0.05).A rising trend of the liver cells apoptosis rate were fonud with increasing of fluoride doses.How ever,at identical fluoride doses,the Pearson correlation coefficient between cell apoptosis and feeding time were-0.71,-0.81 and-0.97(P 0.05).The results indicated that the cell apoptosis increased in an obvious dose-dependent manner and tend to decline with extension of exposure time.Conclusion Chronic fluorosis could cause steady lipid peroxidation and protean apoptosis in liver of rats.Apoptosis may be modulated by more mediators during fluorosis." @default.
- W2360098703 created "2016-06-24" @default.
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- W2360098703 date "2013-01-01" @default.
- W2360098703 modified "2023-09-24" @default.
- W2360098703 title "Time-effect and dose-effect of fluoride on lipid peroxidation and cell apoptosis of liver cells in rats" @default.
- W2360098703 hasPublicationYear "2013" @default.
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