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- W2360100400 abstract "Objective To study the application value ATP bioluminescence tumor chemosensitivity assay (ATP-TCA) directed individual neoadjuvant chemotherapy in patients with non-small cell lung cancer (NSCLC).Methods The study included 79 patients with stage Ⅱ~Ⅲ NSCLC.We tested the specimens from 40 patients for chemosensitivity using ATP-TCA.32 were given the most suitable regimen according to testing,and 39 were allocated to receive a standard regimen of platinum-containing doublet chemotherapy as controls.Results Available evaluation of specimen is 92.5%.Four platinum-containing combined chemotherapy regimens:GEN and DDP (GP) regimen,DOC and DDP(DP) regimen,NVB and DDP(NP) regimen,TAX and DDP(TP) regimen were carried out,and the in vitro effective rates of GP,DP,NP and TP were 81.1%,78.4%,62.2% and 59.5%,respectively.The response rate of neoadjuvant chemotherapy and the resection rate were 78.1% and 93.8% in test group,64.1% and 82.9% in control group,respectively(P0.05). But the response rate evaluated by pathological evaluation was 78.1% for the test group,much better than the control group's 54.3% (P0.05).Conclusions ATP-TCA might be useful in planning individualized neoadjuvant chemotherapy regimen for NSCLC patient.Effect of neoadjuvant chemotherapy should be evaluated by the grading of pathological changes." @default.
- W2360100400 created "2016-06-24" @default.
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- W2360100400 date "2008-01-01" @default.
- W2360100400 modified "2023-09-23" @default.
- W2360100400 title "Application of adenosine triphosphate tumor chemosensitive assay system to individual neoadjuvant chemotherapy for non-small-cell lung cancer" @default.
- W2360100400 hasPublicationYear "2008" @default.
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