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- W2360102984 abstract "[Purpose] To investigate the expressions of transforming growth factor beta receptor 1 (TGFβR1)and smads proteins (smad2/3,smad4,smad7) in gastric adenocarcinoma and their relationship with clinicopathological features.[Methods] TGFβR1,smad2/3,smad4 and smad7 were detected by immunohistochemical methods in 80 gastric adenocarcinoma tissues and 20 normal gastric mucosa.[Results] The positive rates of TGFβR1,smad2/3 and smad4 were lower in gastric adenocarcinoma tissues than those in normal gastric mucosa,while the positive rate of smad7 was higher in gastric adenocarcinoma tissues than that in normal gastric mucosa (P0.05).The expressions of TGFβR1 and smad2/3 related to TNM staging,while smad4 and smad7 related to tumor differentiation,depth of invasion and lymph node metastasis (P 0.05).The expression of TGFβR1correlated positively with smad2/3(r=0.429,P=0.000),negatively with smad7(r=-0.522,P= 0.000).[Conclusion] TGFβR1,smad2/3,smad4 and smad7 might play important roles in carcinogenesis and progress of gastric adenocarcinoma." @default.
- W2360102984 created "2016-06-24" @default.
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- W2360102984 date "2012-01-01" @default.
- W2360102984 modified "2023-09-23" @default.
- W2360102984 title "Expressions of TGFβR1 and Smads Proteins in Gastric Adenocarcinoma" @default.
- W2360102984 hasPublicationYear "2012" @default.
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