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• W236011876 abstract "Publisher Summary This chapter discusses the interaction between adenocorticotropic hormone (ACTH) and beta-endorphin at the central nervous system (CNS) level. Both, adenocorticotropic hormone (ACTH) and beta-endorphin, two centrally acting peptides are fragments of the same 31,000 molecular weight precursor in the pituitary and brain. s-endorphin is known to induce catalepsy, muscular rigidity, profound analgesia, and inhibition of sexual behavior as a result of opiate receptor stimulation. All these effects are reversed by naloxone. A considerable number of independent investigations indicate that besides the stretching-yawning syndrome (SYS), ACTH administration causes some behavioral changes opposite to those induced by s-endorphin or morphine. Thus, ACTH stimulates sexual behavior, induces hyperalgesia in rats, antagonizes the effect of morphine on evoked potentials in the spinal cord, and antagonizes morphine-induced stereotyped behavior in mice. The chapter also discusses that the effects of ACTH 1-24 and s-endorphin are reciprocally suppressed when the two peptides are simultaneously injected." @default.
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• W236011876 date "1983-01-01" @default.
• W236011876 modified "2023-10-17" @default.
• W236011876 title "Interaction Between ACTH and Beta-endorphin at the CNS Level" @default.
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• W236011876 doi "https://doi.org/10.1016/b978-0-08-029804-7.50043-3" @default.
• W236011876 hasPublicationYear "1983" @default.
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