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- W2360121181 abstract "Objective:To ivestigate the possible effects on normal bone marrow derived mesenchymal stem cells(MSCs) when co-cultured with myeloma cell line U266.Methods:Bone marrow MSCs from normal subjects were co-cultured with U266 by transwell.On the given time point,the levels of TNF-α in the medium,the mRNA expression levels of Dickkopf 1(DKK1) and hepatocyte growth factor(HGF) were mesured.Results:No evident morphologic and proliferative alterations could be observed in bone marrow derived MSCs after co-cultured with U266,and there was also no detectable increase in the level of TNF-α in superant of the co-culture system.However,the mRNA expression levels of DKK1 and HGF were upregulated in bone marrow MSCs after 5 days' co-culture with U266.Conlusion:The cross-talk between bone marrow MSCs and U266 induced dysregulation of DKK1 and HGF,which might be involved in the pathogenesis of multiple myeloma." @default.
- W2360121181 created "2016-06-24" @default.
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- W2360121181 date "2011-01-01" @default.
- W2360121181 modified "2023-09-23" @default.
- W2360121181 title "The cross-talk between bone marrow derived mesenchymal stem cells(MSCs) and U266 cell line dysregulated the expression of DKK1 and HGF in MSCs" @default.
- W2360121181 hasPublicationYear "2011" @default.
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