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- W2360131633 abstract "Objective: To observe the effects of carbamazepine (Carb) on naloxon-evoked withdrawal syndrome and ACTH in morphine(Mor) dependent rats. Methods: Mor dependent rats model was built by sc gradually increased doses of Mor twice daily; withdrawal syndromes were precipitated by ip naloxone 1 mg·kg -1, then were observed and scored; serum ACTH concentration was measured by Immulite. Results: Both Carb 100 mg·kg -1 and Carb 200 mg·kg -1 decreased the scores of withdrawal syndromes (P0.05); the ACTH levels of Carb 100 mg·kg -1 group were maintained normal while those of the other two groups increased significantly. Conclusion: Carbamazepine can effectively relieve the withdrawal syndromes in morphine dependent rats when given in proper dose." @default.
- W2360131633 created "2016-06-24" @default.
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- W2360131633 date "2003-01-01" @default.
- W2360131633 modified "2023-09-23" @default.
- W2360131633 title "EFFECTS OF CARBAMAZEPINE ON WITHDRAWAL SYNDROME AND ACTH IN MORPHINE DEPENDENT RATS" @default.
- W2360131633 hasPublicationYear "2003" @default.
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