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- W2360136918 abstract "AIM:To investigate the expression of the AnnexinⅡ gene in human breast cancer cell lines,and to determine the relationship between the expression level of AnnexinⅡ gene and invasive capacity. METHODS:The expression of AnnexinⅡ at mRNA and protein levels were measured respectively by SYBR real-time fluorescent quantitative PCR and Western Blotting in four human breast cancer cell lines(MDA-MB-435S,MDA-MB-231,ZR-75-30,MCF-7). The distribution of AnnexinⅡ protein in these four breast cancer cell lines was measured by immuocytochemistry. The invasive capacity of the cell lines was determined by Millicell chamber assay. RESULTS:The expression level of AnnexinⅡ mRNA was 0.67±0.21,0.38±0.03,0.05±0.03 and (4.06±0.81)×10-5 in MDA-MB-435S,MDA-MB-231,ZR-75-30 and MCF-7 cells,respectively. The expression level of AnnexinⅡ protein was respectively 1.47±0.06,1.10±0.05,0.70±0.03 and 0.09±0.01 by Western Blotting,and 3423±312,2767±147,2001±245 and 353±128 by immunocytochemistry. There was significant difference in AnnexinⅡ mRNA and protein levels between any two of these cell lines (P0.05). The invasive capacity was as follows:MDA-MB-435S was 135.3±7.6,MDA-MB-231 was 147.2±8.9,ZR-75-30 was 79.4±2.9,MCF-7 was 15.3±4.4; there was significant difference between ZR-75-30 and MCF-7 (P0.05),while there wasn't significant difference between MDA-MB-435S and MDA-MB-231 (P0.05).CONCLUSION:AnnexinⅡ expression level is positively related to the invasive ability of these four human breast cancer cell lines in vitro." @default.
- W2360136918 created "2016-06-24" @default.
- W2360136918 creator A5010959826 @default.
- W2360136918 date "2008-01-01" @default.
- W2360136918 modified "2023-09-23" @default.
- W2360136918 title "Expression of Annexin II in four human breast cancer cell lines and its significance" @default.
- W2360136918 hasPublicationYear "2008" @default.
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