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- W2360144979 abstract "Objective To research the variation of tumor necrosis factor-α(TNF-α) in broncho-alveolar lavage fluid(BALF) and expression of transforming growth factor-β1(TGF-β1)in lung tissue in experimental silicotic fibrosis model of mice,and effects of Interferon-γ(IFN-γ) on them.Methods Ninty-six femail ICR mice were randomly divided into three groups:silicotic fibrosis model group,IFN-γ treated group and control group(n=32,each).Silicotic fibrosis model were constructed by intratracheal exposure method(intratracheal injecting SiO2 suspension),mice of control group were administered by intraperitoneal infusion of 0.9% NaCl solution(0.1 ml).After model build,mice were administered by intraperitoneal infusion of 0.9% NaCl solution(0.3 ml)every day in silicotic fibrosis model group and control group,but IFN-γ treated group were administered by intraperitoneal injecting IFN-γ(1.0 × 104 /0.3 ml,per day).Eight mice in each group were respectively killed at day 7,14,21 and 28.The level of TNF-α in BALF was determined by ELISA,and the expression of TGF-β1 in lung tissue was analyzed by immunohistochemistry.The effects of IFN-γ on them were observed.Results At day 7,14,21 and 28,the expressions of TGF-β1 in lung tissue in different time point after inbreathing SiO2 suspension were all significantly increased in silicotic fibrosis model group comparing with the control group(all P 0.01).The rush hour of expression was at day 7.At day 7,14,21 and 28 after the treatment of IFN-γ,the expressions of TGF-β1 in lung tissue were notably decreased comparing with the silicotic fibrosis model group(P 0.01 or P 0.05),but higher than those in the control group(all P 0.01).The level of TNF-α in BALF of silicotic fibrosis model group was significantly increased comparing with the control group(all P 0.05).Level of TNF-α in BALF was decreased in IFN-γ treated group comparing with the silicotic fibrosis model group(P 0.05),but still higher than those in control group(all P 0.05).Conclusions IFN-γ may restrain the process of lung fibrosis and inhibit the improvement of lung fibrosis by means of preventing the expression of TGF-β1 and the level of TNF-α in mice of silicotic fibrosis." @default.
- W2360144979 created "2016-06-24" @default.
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- W2360144979 date "2010-01-01" @default.
- W2360144979 modified "2023-09-24" @default.
- W2360144979 title "Effects of IFN-γ on TNF-α and expression of TGF-β_1 in experimental silicosis mice" @default.
- W2360144979 hasPublicationYear "2010" @default.
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