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- W2360145103 abstract "Objective:To investigate the clinical efficacy and safety of mirtazapine replacing tricyclic antidepressants(TCAs)in the treatment of depression.Method:The patients with depression who had received 6-week treatment of TCAs(enough dose,less than improved)were randomly assigned into two groups.The mirtazapine group was substituted mirtazapine for TCAs gradually,and the TCAs group still received TCAs.The efficacy was assessed with Hamilton depressive scale(HAMD),global assessment scale(GAS),clinical global impression scale severity of illness(CGI-SI)at baseline and at the end of 1st,2nd,4th,8th week after treatment.Side effects were evaluated with treatment emergent symptom scale(TESS).Results:In mirtazapine group,the scores of HAMD、GAS、CGI-SI were significantly improved at the end of 2nd week after treatment.In TCAs group,scores of HAMD,GAS were significantly improved at the end of 4th week,and score of CGI-SI decreased significantly at the end of 8th week.Conclusion:Mirtazapine replacing TCAs in the treatment of depression is safe and effective." @default.
- W2360145103 created "2016-06-24" @default.
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- W2360145103 date "2007-01-01" @default.
- W2360145103 modified "2023-09-23" @default.
- W2360145103 title "A comparative study of tricyclic antidepressants replaced by mirtazapine in treatment of depression" @default.
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