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- W2360147643 abstract "Objective To investigate the expression and distribution of vascular endothelial growth factor receptors:VEGFR-1 and VEGFR-2. Methods Immunohistochemical method and reverse transcriptase-PCR were used to study the expression and distribution of VEGF receptor protein and mRNA of the lumber segmental rat spinal cord tissue in male adult Wistar rats. Results Both VEGFR-1 and VEGFR-2 were expressed in the microvessels of normal rat spinal cord tissue. Besides, the immunoreactivities of VEGFR-2 were mainly in the neural tissue, such as motor neurons, glial cells and nerve fibers that located in the white matter. In the spinal cord tissue, the expression of VEGFR-2 mRNA was higher than that of VEGFR-1 (P0.05).Conclusion VEGF acts on VEGFR-1 and VEGFR-2 expressed in microvessels to promote angiogenesis of the intraneural vessels and maintain the homeostasis of neural microenvironment. The neurotrophic and neuroprotective effects of VEGF are mediated via VEGFR-2, which establishes the experimental and theoretical foundation in the further treating spinal cord injures with VEGF." @default.
- W2360147643 created "2016-06-24" @default.
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- W2360147643 date "2004-01-01" @default.
- W2360147643 modified "2023-09-25" @default.
- W2360147643 title "Expression of vascular endothelial growth factor receptors in rat spinal cord tissue" @default.
- W2360147643 hasPublicationYear "2004" @default.
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