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- W2360150186 abstract "[Objective] XIAP-/- fibroblasts were used to detect the effect of Xaf1 on cell apoptosis without XIAP and to investigate the mechanism of Xaf1 induces cell apoptosis. [Methods] The effect of Xaf1 on cell apoptosis were measured by flow cytometry. The sub-cellular localization of Xaf1 in XIAP-/- fibroblasts was estimated by immunofluoresces assay. The effect of Bcl2 on Xaf1 induced apoptosis were measured by DNA content flow cytometry after co-transfection. Regulation cytochrome C releasing by Xaf1 was measured by cytochrome C flow cytometry. [Results] Flow cytometry demonstrated that Xaf1 dramatically cooperated with TNFα to induce in XIAP-/- fibroblasts apoptosis, the peak was 27%. Introduction of Bcl2 in XIAP-/- fibroblasts inhibited Xaf1 induced apoptosis, the peak decreased from 28% to 6%. Xaf1 released cytochrome C without XIAP, the peak was 21%.[Conclusions] Xaf1 releases cytochrome C and induces cell apoptosis by a caspase independent mechanism." @default.
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- W2360150186 date "2008-01-01" @default.
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- W2360150186 title "Investigation of Mechanism of Xaf1 Induction Apoptosis in XIAP -/- Fibroblasts" @default.
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