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- W2360152422 abstract "Objective To identify the possible alterations of brain functioning in prefrontal lobe and hippocampus in patients with adolescence-onset schizophrenia using proton magnetic resonance spectroscopy (~1H-MRS).Methods ~1H-MRS was performed on prefrontal lobe and hippocampus in 21 patients(13-17 years;mean age:15.9±1.9 years;12 boys,9 girls)and 20 age-,gender-and education-matched normal controls(14-17 years;mean age:15.8±1.6 years;10 boys,10 girls).The NAA,Cho and Cr were measured and the ratios of NAA/Cr and Cho/Cr were determined.Spectral data were analyzed by t test.Results The NAA/Cr ratio in left prefrontal lobe in patients was lower than that in normal controls (1.56±0.81 vs.2.09±0.81,t=2.101,P0.05),and the NAA/Cr and the Cho/Cr in right prefrontal lobe were lower in patients than in normal controls(NAA/Cr:1.84±0.42 vs.2.58±0.83,t=3.660, P0.01;Cho/Cr:1.25±0.17 vs.1.51±0.38,t=3.226,P0.01),while the Cr in right prefrontal lobe was higher in patients than in controls(3.8±1.9 vs.2.8±1.3,t=-2.039,P0.05).In left hippocampus,the NAA/Cr ratio in patients was lower than that in controls(1.33±0.34 vs.1.64±0.56, t=2.135,P0.05).Conclusion Our results support that patients with adolescence-onset schizophrenia have damage of neuronal integrity and dysfunction in the bilateral prefrontal lobe and left hippocampus." @default.
- W2360152422 created "2016-06-24" @default.
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- W2360152422 date "2007-01-01" @default.
- W2360152422 modified "2023-09-25" @default.
- W2360152422 title "A proton magnetic resonance spectroscopy imaging study on prefrontal lobe and hippocampus in patients with adolescence-onset schizophrenia" @default.
- W2360152422 hasPublicationYear "2007" @default.
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