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- W2360168672 abstract "Objective To explore the heart protection in very low birth weight premature infants with respiratory distress syndrome(RDS) after using budesonide combined with pulmonary surfactant(PS),and evaluate the therapeutic effect of combination of budesonide and PS. Methods Thirty premature infants with gestational age34 weeks,birth weight 1 500 g and RDS within 4 hours after birth were randomly divided into the PS+ budesonide group and PS group,who were hospitalized in Maternal and Child Health Hospital of Nanjing form Aug.2010 to Mar.2011.PS and budesonide were used in PS+ budesonide group(per 70 mg PS adding budesonide 0.25 mg),in which PS dose was 70 mg·kg-1,and budesonide dose was 0.25 mg·kg-1.Patients in PS group only used PS,in which dose was 70 mg·kg-1.Tracheal inhalation of PS or PS+budesonide was performed in both groups 30 to 60 minutes after births.Serum creatine kinase myocardial isoenzyme(CK-MB) and troponin were detected in both groups in 1 day,7 days and 14 days.Cardiac functions were evaluated by using echocardiography,and the parameters included left ventricular ejection fraction(LVEF),right ventricular ejection fraction(RVEF),ratio of peak E velocity and peak A velocity of mitral flow and tricuspid flow(MVE/A and TVE/A) and LV-Tei index. Results CK-MB and troponin in PS+budesonide group were significantly lower than those in the control group on the 14th day(Pa0.05);and LVEF was significantly higher on the 14th day(P0.05);and RVEF was significantly higher on the 7th day,14th day(Pa0.05).MVE/A and TVE/A were increased in both groups.But,PS+budesonide group had significant differences compared with the PS group of MVE/A on the 14th day(MVE/A),and TVE/A on the 7th day and 14th day(Pa0.05).LV-Tei index in PS+budesonide group was significantly lower(P0.05). Conclusions Cardiac function can be quickly improved in very low birth weight premature infants with RDS after using budesonide and PS." @default.
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- W2360168672 date "2012-01-01" @default.
- W2360168672 modified "2023-09-26" @default.
- W2360168672 title "Protection of Pulmonary Surfactant Combined with Budesonide on Heart Function of Very Low Birth Weight Premature with Respiratory Distress Syndrome" @default.
- W2360168672 hasPublicationYear "2012" @default.
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