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- W2360174906 abstract "AIM To prepare saponins of panax notoginseng(PNS)/β-ecdysone(EDS)compound liposomal gel and study the drug percutaneous absorption in vitro.METHODS The PNS/EDS compound liposomes were prepared by the film-dispersion method.The compound liposome formulation was optimized by the orthogonal experimental design and car- bomer was added as a supportive base for the preparation of liposomal gel.Drug permeation tests were performed through excised rat skin in diffusion ceils.RESULTS The final liposomal formulation was as follows:lecithin:cholesterin=9: 1,Rg_1 content was 40 g·L~(-1),EDS content was 3g·L~(-1),lipid:drug=5:1,and the highest accumulative drug concen- tration in the skin was obtained when the content of carbopol was 1%.CONCLUSION The liposomal gel has the ability to increase the drug concentration in the excised rat skin,which can improve the bioavailability of the local skin." @default.
- W2360174906 created "2016-06-24" @default.
- W2360174906 creator A5054982110 @default.
- W2360174906 date "2007-01-01" @default.
- W2360174906 modified "2023-09-23" @default.
- W2360174906 title "Study on preparation and transdermal drug delivery of saponins of panax notoginseng compound liposomal gel" @default.
- W2360174906 hasPublicationYear "2007" @default.
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