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- W2360178501 abstract "In addition to homografts and xenografts,the use of nerve prostheses that are made of biocompatible materials could be one of the most applicable therapeutical approaches to central nerve system repair.In the present study,using biocompatible silk fibroin(SF) from bombyx mori and tussah silk,we prepared non-woven nanofibers(SF nanofibers) and analyzed the behavior of astrocytes grown on these nanofibers.Results showed that astrocytes displayed a high affinity to SF nanofibers: they grew in paralelle along the fibers and exhibited a well-arranged GFAP expression.When part of the cell bodies was in a direction perpendicular to the nanofibers,sharp turns were observed,forming a clear border between cells and surroundings where the fibers were possibly enwrapped.Moreover,time-lapse video analysis showed that astrocytes randomly migrated the first several hours after plating.Once they came in contact with a fiber,they kept migrating using the fiber as a rail.Taken together,these data indicate that,not only do the regenerated silk fibroin nanofibers control the growth of astrocytes but lead the migration of these cells as well,making these materials the promising candidates for therapeutic approaches to promote the regeneration of CNS after injury." @default.
- W2360178501 created "2016-06-24" @default.
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- W2360178501 date "2009-01-01" @default.
- W2360178501 modified "2023-09-24" @default.
- W2360178501 title "Study on Regenerated Silk Nanofibers in Supporting and Conducting the Growth and Migration of Astrocytes" @default.
- W2360178501 hasPublicationYear "2009" @default.
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