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- W2360181738 abstract "OBJECTIVE To observe the effect of Telmisartan on congtive function and the expression of Ghrelin receptor in diabetic rats.METHODS 40 rats were divided into the normal control group,diabetic model group,the Telmisartan treatment group randomly.Streptozotocin-diabetic rat model was established.The diabetic rats were treated with Telmisartan for 12 weeks.Then,the learning and memory abilities of rats were tested with the Morris water maze.The mRNA level and protein level of GHSR in hippocampus were detected by RT-PCR and immunohistochemistry methods.RESULTS Compared with diabetic model group,the Telmisartan treatment group showed a significant decrease in the mean time of escape latencies(P0.05)and an increase in percentage of time spent in the the central area and the number of through the original platformposition(P0.05).The protein expression of GHSR and the abundance of GHSR in hippocampus elevated significantly(P0.05).CONCLUSION It is concluded that Telmisartan could improve learning and memory in diabetic rat through increasing the expression of GHSR." @default.
- W2360181738 created "2016-06-24" @default.
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- W2360181738 date "2008-01-01" @default.
- W2360181738 modified "2023-09-24" @default.
- W2360181738 title "Effect of Telmisartan on learning and memory and expression of Ghrelin receptor in diabetic rats" @default.
- W2360181738 hasPublicationYear "2008" @default.
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