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- W2360186021 abstract "Objective:To investigate the biliary excretion of 9-nitrocamptothecin(9-NC)after intravenous administration of 9-NC liposome to rats.Methods:The specific and accurate HPLC method was developed for quantifying 9-nitrocamptothecin in bile samples of rats.The lactone and total 9-NC concentraions as well as lactone percentage versus time profiles in blank bile in vitro were determined.The ratios of cumulative excretion in bile to the administered dose were determined at different time following intravenous administration of 3 mg·kg-1 9-NC solution or liposome to rats.Results:Lactone stability in rat bile samples was so poor that lactone 9-NC concentration as well as lactone percentage decreased quickly with time in blank bile in vitro.But total 9-NC concentration remained unchanged.After intravenous administration of 9-NC solution or liposome,the ratios of cumulative excretion in bile to the administered dose were 7.9% and 8.1%,respectively.Conclusion:Liposomal encapsulation has little effect on biliary excretion of 9-NC after intravenous administration to rats." @default.
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- W2360186021 date "2007-01-01" @default.
- W2360186021 modified "2023-09-24" @default.
- W2360186021 title "Biliary excretion of 9-nitrocamptothecin after intravenous administration of 9-nitrocamptothecin liposome to rats" @default.
- W2360186021 hasPublicationYear "2007" @default.
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