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- W2360192564 abstract "The redox sensitive methoxy poly(ethylene glycol)-SS-polyethylenimine(mPEG-SS-PEI) was successfully synthesized,and the disulfide bond in the above polymer was characterized by TLC.The results of agarose gel electrophoresis showed that the mPEG-SS-PEI-pEGFP complex was stable in DMEM containing 10% fetal bovine serum.The transmission electron microscope observation showed that the particle size of the disulfide bond-free mPEG-PEI-pEGFP complex and mPEG-SS-PEI-pEGFP complex were both about 200 nm.Moreover,the transfection efficiency of mPEG-PEI-pEGFP complex and mPEG-SS-PEI-pEGFP complex in U87 cells were determined by fluorescence microscopy and FACS flow cytometry.The qualitative and quantitative test results indicated that the transfection efficiency of mPEG-SS-PEI-pEGFP in U87 cells was significantly enhanced in comparison with that of mPEG-PEI-pEGFP.It could be contributed to the PEG fraction was broken from the mPEG-SS-PEI-pEGFP complex by reduction under the high concentration of glutathione in cells,so that the proton pump effect of PEI was restored.Further,the in vitro cytotoxicity of the polymer containing disulfide bond was not significantly increased compared with the mPEG-PEI." @default.
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- W2360192564 date "2012-01-01" @default.
- W2360192564 modified "2023-09-22" @default.
- W2360192564 title "Preparation of Redox Sensitive Methoxy Poly(ethylene glycol)-SS-polyethylenimine as a Non-viral Gene Delivery Vector" @default.
- W2360192564 hasPublicationYear "2012" @default.
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