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- W2360196923 abstract "Objective: To research the relationship between acute pancreatitis(AP) liver damage and interleukin-6(IL-6) levels in serum.Methods: Ninety-six acute pancreatitic patients were assigned into two groups as mild(MAP) and severe(SAP) group.Another 34 healthy controls were also involved in this study.The serum levels of ALT,AST,TB,ALB,LDH,AKP,γ,GT and IL-6 were compared among the two acute pancreatitis groups and the control group.Results: The incidence rate of liver damage in 96 cases of acute pancreatitis was 60.42%.The serum levels of liver function either between SAP group and MAP group or between AP groups and control group were significantly different(all P0.01) before treatment.In both AP groups,the serum levels of ALT,AST,TB,LDH,AKP,and γGT were all decreased but ALB levels in SAP were increased after treatment(all P0.05).The serum levels of IL-6 in acute pancreatitis patients were higher than in control group(P0.01) and decreased after treatment(P0.01).In AP patients with liver damage,and the IL-6 levels were much higher than in patients without liver damage and the controls(both P0.01).The positive correlation was discovered between serum levels of IL-6 and ALT or AST among acute pancreatitic patients with liver damage(r=0.64,P(0.01;)r=0.58,P0.01),and IL-6 had no relations to the other indices.The sensitivity and specificity of the liver function changing indices such as ΔALT=-20.50 U/L,ΔAST=-8.50 U/L and ΔIL-6=-36.23 ng/L in predicting acute pancreatitis severity degree were higher in acute pancreatitis with liver damage patients.Conclusion: The incidence rate of liver damage in acute pancreatitis was higher.The degrees of liver damagement in SAP were much higher than in MAP.The serum levels of IL-6 in acute pancreatitic patients were significantly higher and its changes were positively correlated with degrees in liver damage.The sensitivity and specificity of ΔALT and ΔAST in acute pancreatitis with liver damage patients were more valuable than those of ΔIL-6 in predicting degrees of acute pancreatitis." @default.
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- W2360196923 date "2006-01-01" @default.
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- W2360196923 title "Clinical Observation of Relationship Between Acute Pancreatitis Liver Damage and Interleukin-6" @default.
- W2360196923 hasPublicationYear "2006" @default.
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