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- W2360207444 abstract "Objective:To investigate the efect of γ-IFN to the radiation damage and radiation fibrotic of the rabbit ureter after cavitas pelvisrute fractionated irradiation.Methods:To establish rabbit radioactive ureteral injury animal models,52 New Zealand rabbits were divided into conventional radiation group,γ-IFN group,and normal controls,except the normal control group,all the rabbit were exposured pelvic cavity by 6MVX,after 5 days exposure of γ-IFN group,treated by 250,000U γ-IFN,once a week,5ml sodium chloride to illuminate conventional radiation group.After four weeks,8 weeks,12 weeks,16 weeks,executed rabbits,take the ureter in the exposure scope.HE dyeing,situ hyb-ridization and immunohistochemical staining method were used to analyze radioactive ureteral injury and fibrosis.Results:HE dyeing,after 4,8,12 weeks,radioactive ureteral injury and fibrosis of the con-ventional radiation group and γ-IFN group were significantly different(P0.05),16 weeks without significant difference(P0.05).TGFβ1 mRNA of the situ hybridization,at 4,8,12,16 weeks after irradiationin conventional radiation group and γ-IFN group had significant difference(P0.05),and were significantly different compared to normal controls(P0.05).The COLⅢ immunohistochemical results in conventional radiation group and γ-IFN group,normal controls had significant difference(P0.05).Conclusion:γ-IFN relieved radioactive ureteral injury,suppressed the step up of the TGFβ1 mRNA in tunica mucosa ureteris,reduced COLⅢ expression,reduced radiation damage and radiation fibrotic of the rabbit ureter." @default.
- W2360207444 created "2016-06-24" @default.
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- W2360207444 date "2010-01-01" @default.
- W2360207444 modified "2023-09-26" @default.
- W2360207444 title "Efect of γ-IFN to the radiation damage and radiation fibrotic of rabbit ureter after cavitas pelvisrute fractionated irradiation" @default.
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