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- W2360219758 abstract "Objective: To investigate the effects of AM gene on high-salt diet rats' blood pressure, heart and renal function. Method: Eighteen male Wistar rats were allocated randomly into three groups: normal diet, high-salt diet with rAAV-D(+) and high-salt diet with rAAV-D(+)-AM group. A high-salt diet (8% NaCl) or normal diet was given for 8 weeks. Blood pressure and urine Alb were observed during the experiment. At the end, we measured rats' heart function. The expression of AM were detected by RT-PCR. Result: High-salt-fed rats developed slightly but significantly higher systolic blood pressure than controls (P 0.01). After delivery of human AM in high-salt diet rats, a maximal blood pressure difference of 15 mmHg was observed (P 0.01). Human adrenomedullin delivery significantly attenuated increase in the amount of urine A1b of rats (P 0.01). And cardiaovascular dynamic assessments were improved at the end of the experiment (P 0.05). The expression of human adrenomedullin was detected in rat main organs. Conclusion: Human adrenomedullin gene can decrease blood pressure and protect heart and renal function in high-salt diet induced hypertensive rats." @default.
- W2360219758 created "2016-06-24" @default.
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- W2360219758 date "2004-01-01" @default.
- W2360219758 modified "2023-09-25" @default.
- W2360219758 title "Delivery of human adrenomedullin gene mediates reductions in blood pressure and the protects heart and kidney function in high-salt diet induced hypertensive rats" @default.
- W2360219758 hasPublicationYear "2004" @default.
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