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- W2360221961 abstract "Objective:To investigate the effects of Astragalus membranaceus injection (黄芪注射液) on content of interleukin6(IL6) and basic fibroblast growth factor (bFGF) in rabbit kidneys with ischemia reperfusion (IR) and to explore the mechanism of Astragalus membranaceus injection in protecting kidney from IR injury.Methods:Twentyfour adult Japanese white rabbits were randomly divided into operational control group,IR group and Astragalus membranaceus injection treatment group (AM+IR group) in the study.The rabbit's left kidney was removed,and artery of right kidney was clasped for one hour and then reperfused 48 hours.The content of serum creatinine (SCr) and content of IL6 and bFGF in the kidney were measured.And the changes in renal structure were detected under electron microscope.Results:The degenerative changes were remarkable under electron microscope in renal tissue in IR group,but the changes in AM+IR group were slightly.The content of SCr and IL6 in kidney in IR group was much more than those in operational control group,and lower than those in AM+IR group,there was a significant difference between these groups (P0.05 or P0.01).The content of bFGF in kidney in IR group was much lower than those in operational control group and AM+IR group(P0.05 or P0.01).Conclusions:The content of IL6 in kidney was increased and the content of bFGF decreased after kidney ischemia reperfusion;AM has the effect of alleviation the renal IR injury by modulation the production of IL6 and bFGF." @default.
- W2360221961 created "2016-06-24" @default.
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- W2360221961 date "2001-01-01" @default.
- W2360221961 modified "2023-09-26" @default.
- W2360221961 title "Effects of Astragalus membranaceus injection(黄芪注射液) on content of interleukin6 and basic fibroblast growth factor in rabbit kidney with ischemia reperfusion" @default.
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