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- W2360240356 abstract "Objective To evaluate the efficacy and the safety of inhaled corticosteroid (1CS) combined with delayed- release theophylline (SRT) as compared to 1CS combined with long-actingβ2 agonist (LABA) in the control of children with moderate to severe asthma. Methods 141 children with moderate -severe asthma, aging from 4-14years, were randomaly divided into group A and B. 73 cases in group A were given fluticasone propionate (FP), with SRT; 68 cases in group B were treated with inhaled salmeterol/fluticasone (SM/FP). Later 12 weeks after treatment, PEFam, FEV1 and clinical effects were evaluated. Results Lung function (PEFam, FEV1) improved significantly after the treatment (P 0.01) and maintained in two groups, however, no significant difference between the two groups, significant decrease were observed in the day and night-time asthma symptom scores after the treatment (P0.01) and maintained in two groups, however, no significant difference between the two groups, the use of rescue medication reduced significantly after the treatment (P0.01)and maintained in two groups, however, no significant difference between the two groups, the adverse reactions showed no significant difference between the two groups. Conclusion Both 1CS combined with SRT and 1CS plus LABA have equivalent effects in the control of moderate to severe asthma of children. Combination use of ICS plus SRT is effective and safe for children with moderate to severe asthma." @default.
- W2360240356 created "2016-06-24" @default.
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- W2360240356 date "2006-01-01" @default.
- W2360240356 modified "2023-09-24" @default.
- W2360240356 title "Comparative study on therapeutic effect and safety of inhaled corticosteroid combined with theophylline or with long-acting β_2 agonist in the control of children asthma" @default.
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