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- W2360243911 abstract "Objective To establish a standard swine model with equal infarct size and heart function decrease theoretically by ligating LAD at the equal coronary blood flow rate point.Methods Twenty-seven Chinese experimental mini-pigs were divided into experimental group (n=12) and control group (n=15).The whole length of left anterior descending coronary artery (LAD) was dissected and the blood flow rate recorded.LAD was ligated at the point of (25.06± 2.50) ml/min and the mid-inferior 1/3 point respectively.All animals underwent serial hemodynamic study immediately followed by magnetic resonance image (MRI).The infarction size was determined by tetrazolium staining at the 5th week.Results The mortality was 16.7% (2/12) and 33.3% (5/15) in the experimental and control groups respectively.There were significant differences in the variations of the infarction size [(484.22± 225.88) mm3 vs (2 986.34± 1 937.13) mm3, P 0.01],dp/dt max (P 0.01),and ejection fraction (EF, P 0.05) of left ventricle between two groups.There were significant differences in dp/dt [Max: (1 546.67± 477.89) mm Hg/s vs (973.77± 208.12) mm Hg/s, P 0.01],and left ventricle pressure [SBP (75.56± 12.59) mm Hg vs (59.03± 6.93) mm Hg, P 0.01;DBP: (6.56± 3.14) mm Hg vs (4.22± 1.41) mm Hg, P 0.05] before and after LAD ligation in the experimental group 5 weeks later.There was high relativity between the blood flow rate and the infarct size (r= 0.752; P 0.01),and EF variation (r= 0.641 90; P 0.05).Conclusion Blood flow rate based LAD ligation may establish a reliable,stable acute myocardial infarction model with equal infarct size and heart function decrease for the pre-clinical study of cardiac regeneration." @default.
- W2360243911 created "2016-06-24" @default.
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- W2360243911 date "2005-01-01" @default.
- W2360243911 modified "2023-09-23" @default.
- W2360243911 title "Establishing standard acute myocardial infarction animalmodel" @default.
- W2360243911 hasPublicationYear "2005" @default.
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