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- W2360245305 abstract "Objective To evaluate the effects of magnesium sulfate and dexamethasone against ischemia-reperfusion injury of the small intestine in SD rats,and explore the mechanism.Methods Rat model of small intestine I/R injury was used.The SD rats were divided into five groups randomly: sham operation group,ischemia-reperfusion group,magnesium sulfate group,dexamethasone group,and magnesium sulfate plus dexamethasone group.The plasma contents of malondialdehyde(MDA),the activity of diamine oxidase(DAO) in plasma were determined and compared,and the pathological changes of intestinal mucosa were examined.Results ① There were evident pathological changes of the intestinal mucosa,elevated contents of MDA and enhanced DAO activity in the ischemia-reperfusion group,compared with those in the sham operation group.② In the magnesium sulfate group and dexamethasone group,the histopathological scores were lower,the contents of MDA and activity of DAO were significantly lower than those of ischemia-reperfusion group,there was no significant difference between magnesium sulfate group and dexamethasone group.③ Though compared with the ischemia-reperfusion group,elevated contents of MDA was shown in the magnesium sulfate plus dexamethasone group,there was no significant difference of activity of DAO and pathological changes between them.Conclusion The results suggest that magnesium sulfate and dexamethasone have a significant protective effects against ischemia-reperfusion injury of small intestine,respectively,but there is no significant protective effect when they are combined." @default.
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- W2360245305 date "2008-01-01" @default.
- W2360245305 modified "2023-09-27" @default.
- W2360245305 title "Protective Effects and Mechanism of Magnesium Sulfate and Dexamethasone against Ischemia-Reperfusion Injury of the Small Intestine in SD Rats" @default.
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