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- W2360260099 abstract "Objective On the base of the establishment of the new concomitant immunity mouse model infected with Schistosoma japonicum,to discuss the cell immunity mechanisms of this new model by observing the dynamic changes of Th1 cytokine(IFN-γ) levels and Th2 cytokine(IL-4) levels in spleen cells stimulated by different antigens. Methods Each mouse was infected with 20±1 cercariea of S.japonicum.20 days after infection,the mice of experimental group were injected with allyl thiourea at the dose of 300 mg/kg every day by intraperitoneal injection.At 0,3,6,9 and 12 weeks after infection,the ELISA was used for the quantitative determination of IFN-γ and IL-4 produced by cultivated spleen cells in vitro after stimulated by soluble worm antigen preparation(SWAP),soluble egg antigen(SEA) and Concanavalin A(ConA). Results The variance tendency of IFN-γ and IL-4 in the routine model and the new model of mice infected with S.japonicum were generally coincident,which showed that the levels of IFN-γ increased at 4-6 weeks after infection,arrived at peak at 7-9 weeks,and then decreased gradually at 10-12 weeks towards the levels of pre-infection;and the levels of IL-4 began increasing gradually at 6 week after infection and continually maintained a high level until 12 weeks.The levels of IFN-γ stimulated by SEA and the levels of IL4 stimulated by SWAP and SEA in the routine model groups were both obviously higher than that in the new model groups(P0.05),while the levels of IFN-γ stimulated by SWAP in the new model groups were significantly higher than that in the routine model groups(P0.05).In addition,the levels of IFN-γ and IL-4 stimulated by ConA were obviously higher than that stimulated by SWAP and SEA in all groups(P 0.05). Conclusion The variance tendency of cellular immune function of both new concomitant immunity mouse model and routine infectious model infected with S.japonicum was generally coincident." @default.
- W2360260099 created "2016-06-24" @default.
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- W2360260099 date "2005-01-01" @default.
- W2360260099 modified "2023-09-26" @default.
- W2360260099 title "DYNAMICS CHANGES OF Th1/Th2 CYTOKINE LEVELS IN THE NEW MOUSE MODELS INFECTED WITH SCHISTOSOMA JAPONICUM" @default.
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