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- W2360278325 abstract "Objective: To study the effect of cell apoptosis on rat pancreatic acinar cells injury in dietary hypertriglyceridemia. Methods: Male SD rats were assigned to one of two experimental groups and fed for 4 weeks with high fat diet or normal diet. Blood samples were taken to measure triglyceride and cholesterol in plasma. Pancreatic acinar cells were isolated by collagenase digestion. Cell viability was determined by typan blue dyeing at different time points. Cells treated with CCK-8 were examined under transmission electron microscope. Expressions of bax and bcl-2 were investigated by RT-PCR. Results: Compared with the normal diet group, the level of triglyceride was increased significantly in high fat diet group(P0.05). Cell mortality obviously increased after 6 h of isolation in high diet group (P0.05). Enzyme vacuoles were observed in cells of normal fat diet group treated with 10pmol/L CCK-8. Cell apoptosis, necrosis and decreased density of intracellular zymogen granules were observed in both groups with 10nmol/L CCK-8 and in high fat diet group with 10pmol/L CCK-8. The ratio of bax to bcl-2 mRNA was significantly higher in high fat diet group(P0.05). Conclusions: The present results indicate high fat diet can induce hypertriglyceridemia in rat and increased triglyceride can injure the pancreatic acinar cells. Pancreatic acinar cells apoptosis and elevated ratio of bax to bcl-2 may play an important role." @default.
- W2360278325 created "2016-06-24" @default.
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- W2360278325 date "2007-01-01" @default.
- W2360278325 modified "2023-09-23" @default.
- W2360278325 title "Effect of cell apoptosis on rat pancreatic acinar cells injury in dietary hypertriglyceridemia" @default.
- W2360278325 hasPublicationYear "2007" @default.
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