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- W2360293211 abstract "Digoxin 0.25 mg were given orally to 8 volunteers ( 3 men and 5 wo men, age 33 ± SD 7 yr)daily for l4 d:The digoxin levels were found to be 1.08± (K14 ng/ml serum and 0.16±0.04 mg in the 24-h,urine-No abnormal changes in ECG and subjective feelings were noted. From d 15 on,amiodarone 0.6 g were given orally together with digoxin for another 7 d.In 3 cases the digoxin dosage was kept the same, and the digoxin levels were l.4 ± 0.4 ng/ml serum(p0.05) and 0.19±0.05 mg in the 24-h urine(p 0-05).In the other 5 cases the digoxin dosage were reduced to half, and thedigoxin levels were 0.81±0.15 ng/ml serum(p0,05) and 0.118±0.021 mg in the urine (p0.05). All 8 cases develo-ped digestive, central nervous or car-diae reactions. The ECG changes included prolongations of P-P, P-R arid Q-T intervals.These results suggest that, when digoxin and amiodarone are.given concom-itantly for 7d,the healthy subjects showed the side reactions of amiodarone, not the toxicity of digoxin." @default.
- W2360293211 created "2016-06-24" @default.
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- W2360293211 date "1986-01-01" @default.
- W2360293211 modified "2023-09-27" @default.
- W2360293211 title "Digoxin-amiodarone combinations in $ healthy Chinese" @default.
- W2360293211 hasPublicationYear "1986" @default.
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