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- W2360306316 abstract "Objective To develop an alleles specific polymerase chain reaction(AS-PCR)method to investigate the novel V617F point mutation of JAK2 gene in the patients with chronic myeloproliferative disease(CMPD)and evaluate its clinical significance.Methods Genomic DNA from bone marrow or peripheral blood mononuclear cells was extracted from 74 patients with CMPD,including 20 cases of polycythemia vera(PV),52 cases of essential thrombocythemia(ET)and 2 cases of chronic idiopathic myelofibrosis(CIMF).AS-PCR was used to amplify the exon 12 of JAK2 gene which harbourd V617F mutation.Among them 20 cases were further confirmed by DNA sequencing.Results The JAK2V617F mutation was identified in 19 of 20 PV(95.0%),25 of 52 ET(48.1%),2 of 2 CIMF patients(100%).Conclusions AS-PCR has been proved to be an available method for detection of JAK2 V617F mutation in CMPD patients by its high sensitivity and specificity.It is simple and convenient for carrying out in clinical laboratories and useful for diagnosis,classification and treatment of CMPD." @default.
- W2360306316 created "2016-06-24" @default.
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- W2360306316 date "2009-01-01" @default.
- W2360306316 modified "2023-09-26" @default.
- W2360306316 title "Detection of V617F point mutation of JAK2 gene by AS-PCR in chronic myeloproliferative disease and its clinical significance" @default.
- W2360306316 hasPublicationYear "2009" @default.
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