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- W2360325842 abstract "Objective:To observe the effect of dendritic cells in spleen of Lewis lung cancer-bearing mice intervened by Sumu and Sumu+Huangqi.Methods:Lewis lung cancer model in mice was established and treated with Sumu(Sm) and Huangqi+Sumu(Hq+Sm).The tumor inhibiting rate,the nhibiting rate of lung metastasis,change of weight and survival time was observed and the phenotype of dendritic cells in spleen was quantified by flow cytometry(FCM)(15d).Results:The body weight was increased in every treatment groups in late stage,while there was no difference among all groups.The decrease of tumor weight was obvious in Sm group(6d) and Hq + Sm(10d)(P 0.05).The inhibiting rate of lung metastasis was increased in two treatment groups especially the Hq + Sm group(P 0.05).The median survival times were 39d in Hq + Sm group,38d in Hq group,35d in Sm group and 24d in control group.The proportion of CD11c +,CD80 +,CD86 + cell population of dendritic cells in negative control group were obviously higher than those in positive control group.The proportion of CD80 + cell population in Hq + Sm group was higher than that of positive control group.The increase of the proportion of CD11c + cell was obvious in Hq + Sm group.There was no difference of the proportion of CD86 + cell population among negative control group,Sm group and Hq + Sm group.Conclusion:The Qi-deficiency and blood stasis compound formula(Hq + Sm) can up-regulate the phenotype of dendritic cells in spleen of Lewis lung cancer-bearing mice and this effect was better than that of its component blood-stasis medicine(Sm)." @default.
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- W2360325842 date "2009-01-01" @default.
- W2360325842 modified "2023-09-24" @default.
- W2360325842 title "Effect of Dendritic Cells in Spleen of Lewis Lung Cancer-bearing Mice of Sumu and Sumu+Huangqi" @default.
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