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- W2360336783 abstract "To evaluate the role of the tumor necrosis factor(TNF) superfamily member FasL and its receptors in immunologic tolerance,we characterized the expression of FasL and its receptors,and their relation with immunoregulation related cytokines.We built a murine model and measured the expressions of soluble FasL,Fas,DcR3,TGF-β,IL-10 in tumor at different phases by using RT-PCR,at the same time we detected the levels of TGF-β and IL-10 in serum by ELISA.At early phases of tumorigenesis,the Fas expression was ahead to DcR3,as time went on,DcR3 expression increased but the expression of Fas was down-regulated.DcR3 and FasL expression up-regulated simultaneously;expression levels of TGF-β and IL-10 were up-regulated with development of tumorigenesis.In addition,the expression levels of FasL,DcR3,TGF-β,and IL-10 were positively related with tumor growth.The results shows that FasL and DcR3 maybe play an important role in inducing immunologic tolerance in tumorigenesis." @default.
- W2360336783 created "2016-06-24" @default.
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- W2360336783 date "2010-01-01" @default.
- W2360336783 modified "2023-09-28" @default.
- W2360336783 title "Analysis of FasL and Fas/DcR3 expression in hepatocellular cancer development" @default.
- W2360336783 hasPublicationYear "2010" @default.
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