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- W2360338162 abstract "Objective: To explore hepatotoxicity of troglitazone on rat hepatocytes. Methods: Following after the establishment of a primary rat hepatocytes model and other non-hepatocytes models (HepG2, Hela and 3T3 cells) derived from three established cell lines and subsequent exposure of troglitazone to rats, the hepatotocyte sensitivities and toxicities of rats were evaluated using WST-1 assay, LDH release assay, formation of reactive oxygen species (ROS), ATP bioluminescence, reduced glutathione level assay, and Annexin-V-FLUOS/Propidium iodide (PI) staining. Results: Troglitazone showed the most toxicity to the primary cultured rat hepatocytes with the lowest IC_(50) value of 26.3±3.1μmol·L~(-1) compared to HepG2, Hela and 3T3 cells. D, L-buthionine-S, R-sulfoximine (BSO) significantly synergised troglitazone cytotoxicity. N-acyl cysteine (NAC) antagonized the hepatotoxicity induced by trogiltazone. The ROS level was positively dependent of the exposure time of trigiltazone in the primary cultured rat hepatocytes. The ATP and GSH levels were decreased proportionally with the concentration and exposure time of troglitazone. Triglitazone could induce the cellulose apoptosis in a dose-dependent manner. Conclusion: Troglitazone becomes more toxic to the primary cultured rat hepatocytes. The hepatocyte apoptosis induced by triglitazone results from the oxidative damage and ATP exhaustion." @default.
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- W2360338162 date "2005-01-01" @default.
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- W2360338162 title "Effects of troglitazone on oxidative damage of primary cultured rat hepatocytes" @default.
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