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- W2360361159 abstract "Objective To investigate how the cholinergic anti-inflammatory pathway influncing the cytokine level in laboratory rats with pancreatitis.Methods 108 Wistar rats were randomly divided into sham group(SG),control group(CG) and tacrine injection group(TG),serum cytokines content variation of TNF-α,IL-6,IL-10 in different period were determined.Results Serum concentrate of cytokines in SG keep a low level,but what in CG were higher than that in SG,which is signifficant statistically(P0.05).The concentrate of TNF-α,IL-6 in TG were higher than that in SG,in each period(P0.05).But much lower than that in CG(P0.05).Serum level of IL-10 in TG start rising in 1 hour,but it has no signifficance comparing to control group(P=0.933).At 12~72h,the IL-10 level rised to a high level in TG,which was higher than in CG(P0.05).Conclusion Tacrine intravenous injection could increased serum protective cytokine IL-10 level,but decreased injury cytokines TNF-α,IL-6 content in laboratory rats with pancreatitis." @default.
- W2360361159 created "2016-06-24" @default.
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- W2360361159 date "2008-01-01" @default.
- W2360361159 modified "2023-09-27" @default.
- W2360361159 title "The research on how tacrine affect the cytokine level in laboratory rats with acute pancreatitis" @default.
- W2360361159 hasPublicationYear "2008" @default.
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