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- W2360395599 abstract "Objective: To investigate the distribution of acquired resistance-related genes and markers of mobile genetic elements,and their relationships in pandrug-resistant Acinetobacter baumannii(PDR-ABA).Methods: From March 2010 to May 2010,20 strains of PDR-ABA were collected from clinical specimen.Then,57 kinds of acquired resistance-related genes against beta-lactams,aminoglycosides,quinolones,and 8 kinds of genetic markers of mobile genetic element were analyzed by PCR.The index cluster analysis was used to investigate their relationships.Results: In 20 strains of PDR-ABA,5 kinds of acquired beta-lactam-resistance genes,4 kinds of acquired aminoglycoside-resistance genes,1 kinds of acquired quinolone-resistance genes,and 5 kinds of genetic markers of mobile genetic elements were detected.Index cluster analysis showed that acquired resistance-related genes were associated with mobile genetic elements.TEM-1,ADC-like,OXA-23,aac(6′)-Ⅰb,ant(2)-Ⅰ,ant(3)-Ⅰ,aphA1 and adeB had close relations with tnpU,ISCR1,IS26,ISaba1;DHA-1 and CARB also had relations with IS903.Conclusion: In this group of PDR-ABA,acquired resistance-related genes played an important role in resistant phenotypes of antimicrobial agents,and acquired resistance-related genes were associated with mobile genetic elements." @default.
- W2360395599 created "2016-06-24" @default.
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- W2360395599 date "2012-01-01" @default.
- W2360395599 modified "2023-09-22" @default.
- W2360395599 title "Index cluster analysis of acquired resistance-related genes and mobile genetic elements in pandrug-resistant Acinetobacter baumannii" @default.
- W2360395599 hasPublicationYear "2012" @default.
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