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- W2360403003 abstract "Objective To investigate the therapeutic effect of adenovirus-transfected CTLA4-Ig on rats with experimental autoimmune encephalomyelitis(EAE) and to provide possible clinical method to treat multiple sclerosis.Methods Inject adenovirus-transfected CTLA4-Ig(AdCTLA4-Ig) into the lateral cerebral ventricle of rats.Then the difference of morbidity of the disease and the neural electrophysiological changes of EAE rats between AdCTLA4-Ig injected group and metasolon treated group were observed.Results The morbidity of EAE rats,brainstem auditory evoked potential(BAEP) and somatosensory evoked potential(SEP) abnormality improved significantly after lateral cerebral ventricle injection of AdCTLA4-Ig compared with metasolon treatment.Conclusions AdCTLA4-Ig has therapeutic effect on EAE rats and its curative effect is better than metasolon." @default.
- W2360403003 created "2016-06-24" @default.
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- W2360403003 date "2007-01-01" @default.
- W2360403003 modified "2023-09-24" @default.
- W2360403003 title "Therapeutic Effect of Adenovirus-transfected CTLA4-Ig on Rats with Experimental Autoimmune Encephalomyelitis" @default.
- W2360403003 hasPublicationYear "2007" @default.
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