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- W2360406951 abstract "[Objective] To investigate the effect of inhibitor PI3K -LY294002 on the expression of Smurf 2 in cultured human proximal tubular epithelial cell line HK-2 induced by TGF-β1. [Methods] The mRNA expression was tested by RT-PCR. The protein expression was examined by Western blot. [Results] The basic levels of Smurf 2 mRNA and protein expression were observed in HK-2 cell line and up-regulated by TGF-β1 in dose-and time-dependent manner (P 0.01). The LY294002 significantly inhibited the enhanced Smurf 2 mRNA and protein expression in HK-2 cell line stimulated by TGF-β1 in dose-dependent manner (P 0.01). [Conclusion] TGF-β1 could up-regulate the expression of Smurf 2 mRNA and protein in vitro. The intracellular signaling transduction pathway is related to PI3K/Akt. LY294002 could inhibit the enhanced Smurf 2 mRNA and protein expression in HK-2 cell line stimulated by TGF-β1." @default.
- W2360406951 created "2016-06-24" @default.
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- W2360406951 date "2007-01-01" @default.
- W2360406951 modified "2023-09-25" @default.
- W2360406951 title "Effect of LY294002 on expression of smad ubiquitin regulatory factor 2 induced by TGF-β1 in HK-2 cell line" @default.
- W2360406951 hasPublicationYear "2007" @default.
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