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- W2360410293 abstract "Purpose To study the immunohistochemical expression of D2-40,CD117,OCT3/4,vimentin,Inhibin,and CK(AE1/AE3) in intratubular germ cell neoplasm unclassified(IGCNU),intratubular seminoma(ITS) and seminoma and to assess the value of these markers in differential diagnosis.Methods The expression of above mentioned antibodies was performed by SP immunohistochemical technique in 7 cases of seminoma(accompanying IGCNU in 3 cases,and ITS in 1 cases) and 3 cases of cryptorchidism.Results D2-40,CD117 was expressed 7/7 and OCT3/4 was expressed 6/7 in seminoma.All cases of seminoma were negative for vimentin,Inhibin and CK(AE1/AE3).The positive expression of D2-40,CD117 and OCT3/4 in 3 cases IGCNU was 1,3,and 2 respectively,the positive expression of vimentin and Inhibin was 2 and 1.All cases of IGCNU were negative for CK(AE1/AE3).D2-40,CD117 and OCT3/4 was expressed in one case of ITS,and vimentin,Inhibin and CK(AE1/AE3) was not expressed.Vimentin and Inhibin were expressed in 3 cases of cryptorchidism,all cases of crytorchidism were negative for D2-40,CD117,OCT3/4 and CK(AE1/AE3).Conclusions CD117 and OCT3/4 is a sensitive and specific marker for the diagnosis of IGCNU and ITS.The combined detection of D2-40,CD117,OCT3/4,vimentin,Inhibin and CK(AE1/AE3) may be important in the diagnosis and differential diagnosis IGCNU and ITS." @default.
- W2360410293 created "2016-06-24" @default.
- W2360410293 creator A5064092187 @default.
- W2360410293 date "2011-01-01" @default.
- W2360410293 modified "2023-09-25" @default.
- W2360410293 title "The immunophenotype features of testicular intratubular germ cell neoplasm unclassified" @default.
- W2360410293 hasPublicationYear "2011" @default.
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