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- W2360414900 abstract "Objective To determine the changes of interleukin-17(IL-17),transforming growth factor-β(TGF-β) and interleukin-6(IL-6) mRNAs in spleens of BALB/c mice infected with Mycoplasma suis.Methods BALB/c mice were infected with purified M.suis,using physiological saline as control.The spleens of mice were collected aseptically on days 1,3,5,7 and 9 after infection respectively,and determined for expressions of IL-17,TGF-β and IL-6 mRNAs by RT-PCR.Results The expression levels of IL-17 and IL-6 mRNAs in spleens of mice on days 1,3,5,7 and 9 after infection were significantly higher than those in control group(P 0.05),and reached peak values on days 5 and 7 respectively.However,the expression levels of TGF-β mRNA on days 1,3,5 and 7 after infection were significantly higher than those in control group(P 0.01),and reached the peak value on day 3.The change tendency of IL-17 was positively related(r = 0.568),while that of TGF-β was negatively related to that of IL-6(r =-0.645).Conclusion The IL-17,TGF-β and IL-6 levels increased in the mice infected with M.suis,and reached peak values on days 5,3 and 7 after infection,which provided an experimental basis for mechanism of immunological regulation of M.suis associated diseases and laid a theoretical foundation of clinical immunotherapy." @default.
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- W2360414900 date "2012-01-01" @default.
- W2360414900 modified "2023-09-26" @default.
- W2360414900 title "Expressions of interleukin-17,transforming growth factor-β and interleukin-6 mRNAs in mouse spleen infected with Mycoplasma suis" @default.
- W2360414900 hasPublicationYear "2012" @default.
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